Search results for "Needle electrode"
showing 2 items of 2 documents
Tumor hypoxia and therapeutic resistance
2008
For many years, the identification of tumor hypoxia, its systematic characterization and the assessment of its clinical relevance were not possible due to the lack of methods suitable for the routine measurement of intratumoral oxygen tensions in patients. In the late 1980s, a novel and clinically applicable standardized procedure was established enabling the determination of tumor oxygenation in accessible primary tumors, local recurrences, and metastatic lesions in patients using a computerized polarographic needle electrode system (Vaupel et al. 1991; Hockel et al. 1991). Within a relatively short period of time, the significance of tumor oxygenation for therapy outcome became evident in…
Tumor Oxygenation and Its Relevance to Tumor Physiology and Treatment
2003
For many years, the identification of tumor hypoxia, its systematic characterization and the assessment of its clinical relevance were not possible due to lack of methods suitable for the routine measurement of intratumoral oxygen tensions in patients. In the late 1980s, a novel and clinically applicable standardized procedure was established enabling the determination of the tissue oxygenation status in primary tumors, local recurrences, and metastatic lesions in patients using a computerized polarographic needle electrode system. Within a relatively short period of time, the significance of tumor oxygenation for therapy outcome became evident in numerous experimental and clinical studies.